Scite color settings2/27/2023 ![]() ![]() The overall study shows efficacy and mechanism of artesunate. The results had also shown a decrease in the expression of transforming growth factor (TGF-β1) and declined small signal mother against decapentaplegic (Smad3). Amongst the six groups, findings showed that the medium-concentration artesunate group (0.92%) efficiently decreased hypertrophic scar formation and significantly reduced fibroblasts and collagen synthesis. Hematoxylin and eosin staining, Van Gieson staining, immunohistochemistry and Western blot analysis were done. On the 56th day, scar samples were collected for histopathology and immunoassay. ![]() On the 28th day, topical artesunate creams were applied twice a day except on the control group. Punched defects were established on each rabbit’s ear which resulted in a hypertrophic scar. Twenty-four New Zealand white rabbits were randomly divided into six groups: control group, matrix group, low-concentration artesunate group (0.48%), medium-concentration artesunate group (0.96%), high-concentrationĪrtesunate group (1.92%) and silicone gel group. The research was designed to study the significance of artesunate (ART) on the expression of transforming growth factor (TGF-β1) and small mother against decapentaplegic (SMAD3) in rabbit's ear hypertrophic scar model. Although several studies reported the efficiency of artesunate in the treatment of malaria, inhibiting fibroblasts and collagen synthesis, the association between artesunate and scar formation is unclear. Artesunate (ART) is the derivative of artemisinin isolated from the traditional Chinese medicine qinghao. ![]()
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